engine Protein Arrays

“To identi­fy poten­tial bio­mark­ers asso­ci­ated with axi­al spon­dyloarth­rit­is, we used the engine bio­mark­er screen­ing ser­vice. As a first step, we had the autoantibody pro­files of 4 patients invest­ig­ated. In the course of this invest­ig­a­tion on Uni­PEx arrays, more than 50 poten­tial anti­gens could be iden­ti­fied. A subar­ray was cre­ated for these can­did­ates and in a second step, a lar­ger num­ber of patients could eas­ily be testet. This allowed us, to fur­ther nar­row down our poten­tial bio­mark­er can­did­ates. These will now be val­id­ated in fur­ther stud­ies on a dif­fer­ent plat­form. The engine pro­tein arrays are a great tool for broad bio­mark­er screen­ing in the field of autoim­mune dis­eases. The engine team has sup­por­ted us through­out the pro­cess and the screen­ing ser­vice has allowed us to focus on our oth­er pro­jects in par­al­lel with the test­ing.”